Innovative treatments in toxicomania

February 2021

This month, Violaine unveils the results of her randomized clinical trial involving cocaine users. Her study involved 78 participants with moderate to severe cocaine use disorder who went into a 10-day detoxification period before being weekly followed for 3 months. Participants were randomly assigned to daily receive a large dose (800 mg) of cannabidiol (CBD) or placebo for 92 days. Her results demonstrated that compared to placebo, CBD was unfortunately not effective in reducing cocaine craving, the risk of relapse or cocaine use. CBD was, however, well tolerated by participants and associated mainly with mild side effects such as diarrhea. Together, her results encourage the development of new pharmacological compounds to treat cocaine use disorder.